The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy

Abstract Objectives Diabetic retinopathy (DRP) is one of the most common microvascular complications diabetes. The pigment epithelium-derived factor (PEDF) a protein that potent angiogenesis inhibitors. effect blood PEDF concentration on DRP formation remains unclear. present study aimed to determine whether plasma effective appearance DRP. Methods consisted 62 patients with diabetes mellitus and 20 healthy participants. patient group included 28 non-proliferative DRP, 13 proliferative 21 diabetic without levels in serum samples were detected through ELISA method. body mass index participants was calculated. Results Serum (1.533 ± 0.233 μg/mL) found be lower (2.163 0.343 than (p=0.002). similar non-DRP groups (p=0.337). level decreased along progression (p=0.001). Conclusions decreases increase grade. Decreased may important predict . Agents containing used intraocularly/systemically for therapeutic purposes prevent vascular near future.